{
  "handle": "marine-collagen-peptides",
  "searchTerm": "(\"marine collagen\" OR \"collagen peptides\" OR \"hydrolyzed collagen\") AND (skin OR joint OR bone)",
  "filtersApplied": "humans[Filter]+AND+(\"randomized+controlled+trial\"[Publication+Type]+OR+\"meta-analysis\"[Publication+Type])",
  "skus": [
    "JV-COLLAGEN400"
  ],
  "generatedAt": "2026-06-02T08:24:34.595Z",
  "generatedBy": "scripts/ingest-pubmed-evidence.ts",
  "source": "PubMed E-utilities",
  "licence": "NCBI public domain (USA federal work)",
  "totalHits": 63,
  "studies": [
    {
      "pmid": "33742704",
      "title": "Effects of hydrolyzed collagen supplementation on skin aging: a systematic review and meta-analysis.",
      "journal": "International journal of dermatology",
      "year": "2021",
      "firstAuthor": "de Miranda RB",
      "authorCount": 3,
      "publicationTypes": "Journal Article, Meta-Analysis, Systematic Review",
      "doi": "10.1111/ijd.15518",
      "url": "https://pubmed.ncbi.nlm.nih.gov/33742704/",
      "abstract": "Skin aging has become a recurring concern even for younger people, mainly owing to increased life expectancy. In this context, the use of nutricosmetics as supplements has increased in recent years. Moreover, numerous scientific studies have shown the benefits of hydrolyzed collagen supplementation in improving the signs of skin aging. The objective of this study was to summarize the evidence on the effects of hydrolyzed collagen supplementation on human skin through a systematic review followed by a meta-analysis of clinical trials focusing on the process of skin aging. A literature search was conducted in the Medline, Embase, Cochrane, LILACS (Latin American and Caribbean Health Sciences Literature), and Journal of Negative Results in BioMedicine databases. Eligible studies were randomized, double-blind, and controlled trials that evaluated oral supplementation with hydrolyzed collagen as an intervention and reported at least one of the following outcomes: skin wrinkles, hydration, elasticity, and firmness. After retrieving articles from the databases, 19 studies were selected, with a total of 1,125 participants aged between 20 and 70 years (95% women). In the meta-analysis, a grouped analysis of studies showed favorable results of hydrolyzed collagen supplementation compared with placebo in terms of skin hydration, elasticity, and wrinkles. The findings of improved hydration and elasticity were also confirmed in the subgroup meta-analysis. Based on results, ingestion of hydrolyzed collagen for 90 days is effective in reducing skin aging, as it reduces wrinkles and improves skin elasticity and hydration."
    },
    {
      "pmid": "37432180",
      "title": "Effects of Oral Collagen for Skin Anti-Aging: A Systematic Review and Meta-Analysis.",
      "journal": "Nutrients",
      "year": "2023",
      "firstAuthor": "Pu SY",
      "authorCount": 7,
      "publicationTypes": "Meta-Analysis, Systematic Review, Journal Article",
      "doi": "10.3390/nu15092080",
      "url": "https://pubmed.ncbi.nlm.nih.gov/37432180/",
      "abstract": "This paper presents a systematic review and meta-analysis of 26 randomized controlled trials (RCTs) involving 1721 patients to assess the effects of hydrolyzed collagen (HC) supplementation on skin hydration and elasticity. The results showed that HC supplementation significantly improved skin hydration (test for overall effect: Z = 4.94, p < 0.00001) and elasticity (test for overall effect: Z = 4.49, p < 0.00001) compared to the placebo group. Subgroup analyses demonstrated that the effects of HC supplementation on skin hydration varied based on the source of collagen and the duration of supplementation. However, there were no significant differences in the effects of different sources (p = 0.21) of collagen or corresponding measurements (p = 0.06) on skin elasticity. The study also identified several biases in the included RCTs. Overall, the findings suggest that HC supplementation can have positive effects on skin health, but further large-scale randomized control trials are necessary to confirm these findings."
    },
    {
      "pmid": "31627309",
      "title": "A Collagen Supplement Improves Skin Hydration, Elasticity, Roughness, and Density: Results of a Randomized, Placebo-Controlled, Blind Study.",
      "journal": "Nutrients",
      "year": "2019",
      "firstAuthor": "Bolke L",
      "authorCount": 4,
      "publicationTypes": "Journal Article, Randomized Controlled Trial",
      "doi": "10.3390/nu11102494",
      "url": "https://pubmed.ncbi.nlm.nih.gov/31627309/",
      "abstract": "The purpose of this randomized, placebo-controlled, blind study was to investigate the effects of the drinkable nutraceutical ELASTEN((R)) (QUIRIS Healthcare, Gutersloh, Germany) on skin aging and skin health. Drinking ampoules provides a blend of 2.5 g of collagen peptides, acerola fruit extract, vitamin C, zinc, biotin, and a native vitamin E complex. This controlled interventional trial was performed on 72 healthy women aged 35 years or older. They received either the food supplement (n = 36) or a placebo (n = 36) for twelve weeks. A skin assessment was carried out and based on objective validated methods, including corneometry (skin hydration), cutometry (elasticity), the use of silicon skin replicas with optical 3D phase-shift rapid in-vivo measurements (PRIMOS) (roughness), and skin sonography (density). The verum group was followed for an additional four weeks (without intake of the test product) to evaluate the sustainability of the changes induced by the intake of the test product. The test product significantly improved skin hydration, elasticity, roughness, and density. The differences between the verum group and the placebo group were statistically significant for all test parameters. These positive effects were substantially retained during the follow-up. The measured effects were fully consistent with the subjective assessments of the study participants. The nutraceutical was well tolerated."
    },
    {
      "pmid": "24401291",
      "title": "Oral intake of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis.",
      "journal": "Skin pharmacology and physiology",
      "year": "2014",
      "firstAuthor": "Proksch E",
      "authorCount": 6,
      "publicationTypes": "Journal Article, Randomized Controlled Trial",
      "doi": "10.1159/000355523",
      "url": "https://pubmed.ncbi.nlm.nih.gov/24401291/",
      "abstract": "Dietary consumption of food supplements has been found to modulate skin functions and can therefore be useful in the treatment of skin aging. However, there is only a limited number of clinical studies supporting these claims. In this double-blind, placebo-controlled study, the effectiveness of the specific bioactive collagen peptide (BCP) VERISOL(R) on eye wrinkle formation and stimulation of procollagen I, elastin and fibrillin biosynthesis in the skin was assessed. A hundred and fourteen women aged 45-65 years were randomized to receive 2.5 g of BCP or placebo, once daily for 8 weeks, with 57 subjects being allocated to each treatment group. Skin wrinkles were objectively measured in all subjects, before starting the treatment, after 4 and 8 weeks as well as 4 weeks after the last intake (4-week regression phase). A subgroup was established for suction blister biopsies analyzing procollagen I, elastin and fibrillin at the beginning of the treatment and after 8 weeks of intake. The ingestion of the specific BCP used in this study promoted a statistically significant reduction of eye wrinkle volume (p < 0.05) in comparison to the placebo group after 4 and 8 weeks (20%) of intake. Moreover a positive long-lasting effect was observed 4 weeks after the last BCP administration (p < 0.05). Additionally, after 8 weeks of intake a statistically significantly higher content of procollagen type I (65%) and elastin (18%) in the BCP-treated volunteers compared to the placebo-treated patients was detected. For fibrillin, a 6% increase could be determined after BCP treatment compared to the placebo, but this effect failed to reach the level of statistical significance. In conclusion, our findings demonstrate that the oral intake of specific bioactive collagen peptides (Verisol(R)) "
    },
    {
      "pmid": "23949208",
      "title": "Oral supplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study.",
      "journal": "Skin pharmacology and physiology",
      "year": "2014",
      "firstAuthor": "Proksch E",
      "authorCount": 6,
      "publicationTypes": "Journal Article, Randomized Controlled Trial",
      "doi": "10.1159/000351376",
      "url": "https://pubmed.ncbi.nlm.nih.gov/23949208/",
      "abstract": "Various dietary supplements are claimed to have cutaneous anti-aging properties; however, there are a limited number of research studies supporting these claims. The objective of this research was to study the effectiveness of collagen hydrolysate (CH) composed of specific collagen peptides on skin biophysical parameters related to cutaneous aging. In this double-blind, placebo-controlled trial, 69 women aged 35-55 years were randomized to receive 2.5 g or 5.0 g of CH or placebo once daily for 8 weeks, with 23 subjects being allocated to each treatment group. Skin elasticity, skin moisture, transepidermal water loss and skin roughness were objectively measured before the first oral product application (t0) and after 4 (t1) and 8 weeks (t2) of regular intake. Skin elasticity (primary interest) was also assessed at follow-up 4 weeks after the last intake of CH (t3, 4-week regression phase). At the end of the study, skin elasticity in both CH dosage groups showed a statistically significant improvement in comparison to placebo. After 4 weeks of follow-up treatment, a statistically significantly higher skin elasticity level was determined in elderly women. With regard to skin moisture and skin evaporation, a positive influence of CH treatment could be observed in a subgroup analysis, but data failed to reach a level of statistical significance. No side effects were noted throughout the study."
    },
    {
      "pmid": "37822045",
      "title": "Low-molecular-weight collagen peptides supplement promotes a healthy skin: A randomized, double-blinded, placebo-controlled study.",
      "journal": "Journal of cosmetic dermatology",
      "year": "2024",
      "firstAuthor": "Seong SH",
      "authorCount": 11,
      "publicationTypes": "Randomized Controlled Trial, Journal Article",
      "doi": "10.1111/jocd.16026",
      "url": "https://pubmed.ncbi.nlm.nih.gov/37822045/",
      "abstract": "BACKGROUND: Oral collagen peptides supplementation was reported to improve skin integrity and counteract skin aging. AIMS: A randomized, double-blinded, placebo-controlled study was conducted to clinically evaluate the impact of low-molecular-weight collagen peptides on the human skin. PATIENTS/METHODS: Healthy adult participants (n = 100) were randomly assigned to receive a test product containing low-molecular-weight collagen peptides or a placebo. Parameters of skin wrinkles, elasticity, hydration, and whitening (melanin and erythema indexes) were measured at baseline and after 4, 8, and 12 weeks. RESULTS: Compared with the placebo group, the average skin roughness, maximum of all peak-to-valley values, maximum peak height of the wrinkle, and average maximum height of the wrinkle were significantly improved in the test group. Parameters of skin elasticity, including overall elasticity, net elasticity, and biological elasticity, were also significantly improved in the test group at Week 12 as compared with the placebo group. Moreover, skin hydration and whitening parameters changed more significantly in the test group than in the placebo group. None of the participants experienced adverse events related to the test product. CONCLUSIONS: Taken together, these findings suggest that low-molecular-weight collagen peptides supplementation can safely ehance human skin wrinkling, hydration, elasticity, and whitening properties."
    },
    {
      "pmid": "29337906",
      "title": "Specific Collagen Peptides Improve Bone Mineral Density and Bone Markers in Postmenopausal Women-A Randomized Controlled Study.",
      "journal": "Nutrients",
      "year": "2018",
      "firstAuthor": "König D",
      "authorCount": 5,
      "publicationTypes": "Clinical Trial, Phase III, Journal Article, Randomized Controlled Trial",
      "doi": "10.3390/nu10010097",
      "url": "https://pubmed.ncbi.nlm.nih.gov/29337906/",
      "abstract": "Introduction: Investigations in rodents as well as in vitro experiments have suggested an anabolic influence of specific collagen peptides (SCP) on bone formation and bone mineral density (BMD). The goal of the study was to investigate the effect of 12-month daily oral administration of 5 g SCP vs. placebo (CG: control group) on BMD in postmenopausal women with primary, age-related reduction in BMD. Methods: 131 women were enrolled in this randomized, placebo-controlled double-blinded investigation. The primary endpoint was the change in BMD of the femoral neck and the spine after 12 months. In addition, plasma levels of bone markers-amino-terminal propeptide of type I collagen (P1NP) and C-telopeptide of type I collagen (CTX 1)-were analysed. Results: A total of 102 women completed the study, but all subjects were included in the intention-to-treat (ITT) analysis (age 64.3 +/- 7.2 years; Body Mass Index, BMI 23.6 +/- 3.6 kg/m(2); T-score spine -2.4 +/- 0.6; T-score femoral neck -1.4 +/- 0.5). In the SCP group (n = 66), BMD of the spine and of the femoral neck increased significantly compared to the control group (n = 65) (T-score spine: SCP +0.1 +/- 0.26; CG -0.03 +/- 0.18; ANCOVA p = 0.030; T-score femoral neck: SCP +0.09 +/- 0.24; CG -0.01 +/- 0.19; ANCOVA p = 0.003). P1NP increased significantly in the SCP group (p = 0.007), whereas CTX 1 increased significantly in the control group (p = 0.011). Conclusions: These data demonstrate that the intake of SCP increased BMD in postmenopausal women with primary, age-related reduction of BMD. In addition, SCP supplementation was associated with a favorable shift in bone markers, indicating increased bone formation and reduced bone degradation."
    },
    {
      "pmid": "37551682",
      "title": "Collagen peptides supplementation improves function, pain, and physical and mental outcomes in active adults.",
      "journal": "Journal of the International Society of Sports Nutrition",
      "year": "2023",
      "firstAuthor": "Kviatkovsky SA",
      "authorCount": 5,
      "publicationTypes": "Randomized Controlled Trial, Journal Article",
      "doi": "10.1080/15502783.2023.2243252",
      "url": "https://pubmed.ncbi.nlm.nih.gov/37551682/",
      "abstract": "INTRODUCTION: Chronic pain affects 19% of adults in the United States, with increasing prevalence in active and aging populations. Pain can limit physical activity and activities of daily living (ADLs), resulting in declined mental and social health. Nutritional interventions for pain currently target inflammation or joint health, but few influence both. Collagen, the most abundant protein in the human body and constituent of the extra cellular matrix, is such a nutraceutical. While there have been reports of reductions in pain with short-term collagen peptide (CP) supplementation, there are no long-term studies specifically in healthy middle-aged active adults. PURPOSE: To determine the effects of daily CP consumption over 3, 6, and 9 months on survey measures of pain, function, and physical and mental health using The Knee Injury & Osteoarthritis Outcomes Score (KOOS) and Veterans Rand 12 (VR-12) in middle-aged active adults. METHODS: This study was a double-blind randomized control trial with three treatment groups (Placebo, 10 g/d CP, and 20 g/d CP). RESULTS: Improvements in ADLs (p = .031, eta(p)(2) = .096) and pain (p = .037, eta(p)(2) = .164) were observed with 10 g/d CP over 6 months, although pain only improved in high frequency exercisers (>180 min/week). Additionally, VR-12 mental component scores (MCS) improved with 10 g/d of CP over 3-9 months (p = .017, eta(p)(2) = .309), while physical component scores (PCS) improved with 20 g/d of CP over 3-9 months, but only in females (p = .013, eta(p)(2)= .582). CONCLUSION: These findings suggest 10 to 20 g/d of CP supplementation over 6 to 9 months may improve ADLs, pain, MCS, and PCS in middle-aged active adults."
    }
  ]
}